Endocrine Abstracts

Glucocorticoids are highly detrimental to skin integrity and function both when used locally for anti-inflammatory treatments and during conditions of raised systemic concentrations such as Cushing’s syndrome. Many of the adverse effects of glucocorticoids on skin are also symptoms associated with natural intrinsic aging and extrinsic photoaging.Locally, glucocorticoid availability is regulated independently of circulating levels by 11β-hydroxy...

Introduction: Single adenoma is the most frequent cause of Primary hyperparathyroidism (HPT1). Surgical excision has a high success rate, particularly when associated with a fast intraoperative intact parathyroid hormone assay (PTHi).Aim: Evaluate the success rate of primary hyperparathyroidism surgery in our unit.Methods: Descriptive study of the last 33 consecutive HPT1 patients who undertook surgery, 27 of which with PTHi. The P...

Introduction: Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is still a matter of debate.Objective: The aim of the present study was to assess the effects of levothyroxine treatment on bone mineral density (BMD) and biochemical bone turnover markers.Methods: We determined thyroid function – TSH and free T4 (FT4), r...

Using qRT-PCR, we found that normal human thyroid follicular cells in culture express the mRNAs for the receptors for vascular endothelial growth factors (VEGFRs). qRT-PCR revealed that the relative production of mRNAs for VEGFRs was neuropilin1=neuropilin2=VEGFR2>VEGFR1 >VEGFR3. Western blotting for phosphoVEGFR2 showed labelling of a 235 kDa protein with few degradation products. VEGFR2 is likely in its active, phosphorylated form, because thyroid cells secrete large...

ACRD presents with clinical features of hyperandrogenism in females similar to those of PCOS (acne, hirsutism, oligomenorrhea, infertility), and precocious puberty in males. Obesity also occurs in some cases. Increased cortisol clearance leads to an increased hypothalamic-pituitary-adrenal axis drive resulting in elevated serum androgen levels and a decreased urinary cortisol metabolite: cortisone metabolite ratio below 0.5 (normal adult range 0.7–1.3). These observations...

Backgroud: Primary hyperparathyroidism is the most common cause of hypercalcemia, which is associated with an increased frequency of hypertension. However, there are no data on the prevalence of primary hyperparathyroidism in patients who present with hypertension.Clinical case: We present the case of a 40-year-old woman with a history of hypertension for ten years. In 2017 she was referred for evaluation of hypercalcemia. The patient denied any symptoms...

Introduction: Male hypogonadism is defined by lower levels of testosterone than expected for age-matched individuals. In primary or hypergonadotropic hypogonadism, LH and FSH show a compensatory elevation to low testosterone levels, while in the secondary or hypogonadotropic hypogonadism the low testosterone levels are a result of insufficient gonadotropin levels. Hyperprolactinemia is a cause of hypogonadotropic hypogonadism. It is not only caused by lactotroph adenomas (prol...

Introduction: Ectopic Cushing syndrome caused by a neuroendocrine tumor is uncommon and it’s diagnosis is often delayed. Optic neuritis is another rare disease, with some cases also associated to neuroendocrine tumors.Case-report: A 43-year-old female was referred to the endocrinology outpatient’s department due to obesity. She had a past history of bilateral optic neuritis of unknown etiology. She complained of weight gain, hair loss, acne, hi...

The aim of the present work was to assess the degree of glycemic control and complications rate through pregnancy and thirteen-years post-partum in women with microalbuminuria (T1DM).Materials and methodsIn total 191 patients with T1DM were enrolled in the study. Based on albuminuria levels in the 1st trimester women were separated into 2 groups (Gr.). Gr.1 – 116 women with normoalbuminuria, Gr.2 – 75 women wit...

BackgroundThyroid nodules with indeterminate cytology represent a therapeutic challenge. The probability of malignancy had been established between 5 and 15%, but it varies among the published data. Nowadays we have molecular tests to help in therapeutic decisions, but they are not available at all centers leaving uncertainty regarding appropriate management.Objectives– To know the percentage of malignan...